2000 Research Forum Abstract
Presented at the 2000 Annual Meeting of the American Academy of Periodontology
Honolulu, Hawaii
Reviewed by the Subcommittee on Research Submissions of the Annual Meeting Committee
1-year Clinical Results Comparing 2 Antibiotic Regimens Following Full Mouth Micro Ultrasonic Debridement
John Y. Kwan, DDS, Oakland, CA, UC San Francisco
Connie L. Drisko, DDS
L. Jane Goldsmith, PhD
David E. Miles, BS, University of Louisville, Louisville, KY
The aim of this 1-year longitudinal study was to compare the adjunctive clinical effects of 2 systemic antibiotic regimens following full mouth micro ultrasonic debridement. Two hundred three (203) consecutive patients were treated in a private practice by full mouth micro ultrasonic debridement (FMMUD) plus a short course of antibiotics. Group M/A (N=101) received FMMUD plus systemic metronidazole 250mg tid and amoxicillin 250 mg tid for 7 days. Group M (N=102) received FMMUD plus metronidazole 250mg tid for 5 days. Full mouth probing depths (PD) were recorded at baseline, 6 weeks and 12 months. Statistical analysis included weighted general linear multivariate model (GLMM) and generalized estimating equations (GEE). Results showed that differences between groups were statistically significant at baseline (P=0.001) using weighted GLMM (weighting based on number of sites per patient contributing to the analysis). Initial mean full mouth probing depths were 3.22mm for M/A and 2.949mm for M. Using the GlMM, differences were statistically significant over 3 visits when the 2 groups were considered together (P=0.00005). Differences between groups over time were statistically significant at P=0.001, with greater mean probing depth reduction occurring in the M/A group. From baseline to 6 weeks, the number of M/A sites with 1mm PD reduction was statistically higher than M (P=0.00005) but was not significantly different between 6 weeks and 12 months (P=0.0292). The number of M/A sites improved by 2mm or more between baseline and 6 weeks (P=0.0007) and the 6 week to 12 month visit (P=0.0203) was significaltly greater than that of the M sites. It can be concluded that probing depth reduction was significantly greater following full mouth micro ultrasonic debridement and a 7 day course of systemic metronidazole plus amoxicillin than full mouth micro ultrasonic debridement plus a 5 day course of metronidazole.